Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization

Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization

PURPOSE The integrin αvβ3 is differentially expressed on neovascular endothelial cells. We investigated whether a novel intravenously injectable αvβ3 integrin-ligand coupled nanoparticle (NP) can target choroidal neovascular membranes (CNV) for imaging and targeted gene therapy. METHODS CNV lesions were induced in rats using laser photocoagulation. The utility of NP for in vivo imaging and ge...

Photodynamic Therapy for Choroidal Neovascularization

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Photodynamic Therapy for Choroidal Neovascularization

Photodynamic therapy is considered investigational when used in combination with one or more of the anti-vascular endothelial growth factor therapies (anti-VEGF), i.e., pegatanib (Macugen), ranibizumab (Lucentis), bevacizumab (Avastin), aflibercept (EyleaTM) as a treatment of CNV associated with agerelated macular degeneration, chronic central serous chorioretinopathy, choroidal hemangioma, pat...

Core/Shell structured nanoparticles for imaging and therapy

Introduction: Nanoparticles have several exciting applications in various fields of biomedicine. It has been found that among different classes of nanoparticles core/shell is most promising for field of nano-medical imaging and therapy due to their distinct advantages. The core/shell type nanoparticles can be generally comprising of two nanoparticles one act as a core (inner ma...

Antibody Targeted Nanoparticles for Imaging and Therapy of Cancer